RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention
نویسندگان
چکیده
منابع مشابه
Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status.
Activating mutations in the K-Ras small GTPase are extensively found in human tumors. Although these mutations induce the generation of a constitutively GTP-loaded, active form of K-Ras, phosphorylation at Ser181 within the C-terminal hypervariable region can modulate oncogenic K-Ras function without affecting the in vitro affinity for its effector Raf-1. In striking contrast, K-Ras phosphoryla...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2021
ISSN: 2218-273X
DOI: 10.3390/biom11030377